knee pain relief

Effective Against

arthritis, bursitis, tendonitis, muscle sprains and strains, low back pain, TMJ disorder, and RSI (carpal tunnel syndrome, neuralgia, etc).

Tissue injury and subsequent inflammation represent a complex series of pathophysiological events resulting in the characteristic signs of heat, redness, swelling, pain, and stiffness.

Inflammation impacts many pain pathways, resulting in pain sensation leading to the damage of cells at the site of injury. The multifocal deliverers of pain need a synergistic, multimodal approach for delivering analgesia. The ingredients selected for Nuwell Natural Pain Relief Cream focus on each element of the inflammatory process that can cause pain and damage tissues.

How does NUWELL Natural Pain Relief Cream Work?

One of the main causes of ongoing tissue damage is the generation of highly reactive molecular species called free radicals. They damage cellular membrane with lipid peroxidation. The main mechanism controlling free radical damage is the scavenging and inactivation of these radicals by the family of enzymes, Superoxide Dismutase (SOD). SOD consists of three isoforms based on the trace element that forms the enzyme’s active site. These SOD isoforms exist as pro-enzymes until they are activated by the insertion of the specific trace element into the active site. The SODs consist of a copper-zinc isoform (most abundant), a copper isoform, and a manganese isoform (mitochondrial). In the body, when injury or inflammation occurs, copper and zinc complexed with amino acids or protein are mobilized from the liver and transported to the site of inflammation.

Nuwell Pain Relief Cream uses orthomolecular treatment to enhance the physiologic mobilization response by delivering to the site of injury organically complexed trace element: amino acid complexes that can be immediately inserted into the SOD active sites and converting the pro-enzyme form to a physiologically active functional enzyme. When activated, these enzymes convert the charged, highly reactive superoxide radicals into non-reactive hydrogen peroxide, thereby preventing further tissue damage.


NUWELL PAIN CREAM uses organic complexes of trace elements to stabilize lysosomal membranes in phagocytes, limiting tissue-damaging enzymes release, such as proteases, lipases, and hyaluronidase. The Mn, Cu, and Zn amino acid complexes also stabilize mast cell membranes, decrease histamine and serotonin release, and reduce vascular permeability and thereby alleviate swelling, redness, and pain and improve recovery.

Tufts University conducted a clinical trial in patients with Transmandibular Joint Disorder (TMJ) to test the formulation’s efficacy against muscle and joint pain. The analgesic was effective as a first- or adjunct-treatment for pain relief, with some patients showing a 68% decrease in pain at period 2. Considering the trial group’s severity of the chronic disease state and their hard-to-manage pain problems, the results are extremely effective. This analgesic product has also been used successfully for neuropathic pain (post-herpetic neuralgia, diabetic neuropathy, etc.).


The product assists the body by providing natural elements to help fight inflammation, pain, and stiffness, with unique outcomes distinct from usual counter-irritants. Clinical trial teams, healthcare professionals, and users report this. Outside the study, faster/shorter healing times were found for injuries like strains, sprains, and RSI. Athletes using the product as a warm-up cream showed increased endurance, reduced lactic acid buildup and muscle spasms, and faster healing times post-injury.

Pain management requires a consistent and comprehensive treatment program. NUWELL PAIN RELIEF cream has been shown to be safe and effective aid in delivering pain relief for all types of pain and stiffness. It has shown benefits as a first-line or as adjunct treatment for both acute and chronic pain.